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Gradually increasing dietary fiber, particularly low-FODMAP options or psyllium, can also help manage constipation without worsening bloating

Exendin-4 has also been shown to reduce response to addictive drugs such as cocaine, heroin, alcohol, and oxycodone

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Implications During Pregnancy: While the benefits of GLP-1 in weight management are promising, studies like those in the British Journal of Clinical Pharmacology emphasize the need for cautious consideration during pregnancy

Compared to GIP, which has normal secretion but poor response in patients with T2D, GLP-1, which has low secretion but preserved response, is an important target in the development of antidiabetic drugs

PMID: 28525404